Investigation of Receptor-Ligand Interaction of Cannabidiol by Molecular Docking Method
نویسندگان
چکیده
Kanabidiol, CB1 ve CB2 reseptörlerine düşük bağlanma eğilimine (afiniteye) sahip psikoaktif özellikleri olmayan bir kanabinoiddir. Ayrıca G proteinine bağlı reseptörler, serotonin reseptörleri opioid ile de aktivite göstermektedir. Bu nedenle kanabidiol uzun zamandır anksiyete, depresyon, refrakter epilepsi gibi nöronal hastalıkların, Parkinson, Alzheimer hastalığı, amyotrofik lateral skleroz sinir sistemi hastalıklarının, enflamatuvar bozukluklar bağışıklık hastalıklarının tedavisinde kullanılmaktadır. güçlü aktivitesi sayesinde yoksunluk sendromu çalışmada iki klasik kanabinoid reseptörü olan CB2, bunlara ilaveten literatür taramaları sonucunda, İnsan Delta-Opioid Reseptörü (δ-OP), Nosiseptin/Orfanin FQ receptor (G protein-coupled 55 - GPR55), Vanilloid (Transient potential vanilloid receptor1 -TRPV1) Serotonin 1A (5-HT1A) tercih edilmiştir. Yapılan moleküler yerleştirme çalışmaları sonucunda CBD'nin CB1, δ-OP, GPR55, TRPV1 5-HT1A için önemli afiniteye molekül olduğu gösterilmiştir.
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ژورنال
عنوان ژورنال: Karadeniz fen bilimleri dergisi
سال: 2023
ISSN: ['1309-4726', '2564-7377']
DOI: https://doi.org/10.31466/kfbd.1214649